Synthesis, structural investigation and biological applications of novel Carbonyl Ruthenium (II) complexes

This work presents the synthesis with moderate to good yields, structural elucidation, and biological studies of novel Ru(II) complexes with potential anticancer and antimicrobial applications. The description emphasizes the reactivity of [Ru(H)₂(CO)(PPh₃)₃] with a plethora of organic ligands, exploring their dynamic coordination behavior, physical-chemical properties, and biological activity. Overall, this work highlights the versatility of Ru(II) complexes in coordinating diverse kinds of ligands, yielding species with tunable properties for medicinal applications. The utilized methods sustain the potential of these complexes as anticancer and antimicrobial agents, provide insight into their biological targets and mechanisms of action, pointing the way to future therapeutic developments with minor drawbacks.