Il ruolo dell'ecografia prenatale nell'infezione congenita da Citomegalovirus

Simonazzi, Giuliana (2008) Il ruolo dell'ecografia prenatale nell'infezione congenita da Citomegalovirus, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Medicina materno infantile e dell'età evolutiva, 20 Ciclo. DOI 10.6092/unibo/amsdottorato/970.
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Abstract

OBJECTIVE: To assess the effectiveness of ultrasound in the antenatal prediction of symptomatic congenital cytomegalovirus infection. STUDY DESIGN: The sonograms of 650 fetuses from mothers with primary cytomegalovirus infection were correlated to fetal/neonatal outcome. Infection status was disclosed by viral urine isolation at birth or CMV tissue inclusions at autopsy. Classification of symptomatic disease was based on postnatal clinical/laboratory findings or macroscopic evidence of tissue damage at autopsy. RESULTS: Ultrasound abnormalities were found in 51/600 (8.5%) mothers with primary infection and in 23/154 congenitally infected fetuses (14.9%). Symptomatic congenital infection resulted in 18/23 and 68/131 cases with or without abnormal sonographic findings, respectively. Positive predictive values of ultrasound versus symptomatic congenital infection was 35.3% relating to all fetuses/infants from mothers with primary infection and 78.3% relating to fetuses/infants with congenital infection. CONCLUSION: When fetal infection status is unknown, ultrasound abnormalities only predict symptomatic congenital infection in a third of cases.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Simonazzi, Giuliana
Supervisore
Dottorato di ricerca
Ciclo
20
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
infezione congenita sintomatica citomegalovirus ecografia counselling prenatale
URN:NBN
DOI
10.6092/unibo/amsdottorato/970
Data di discussione
9 Giugno 2008
URI

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