Multifunctional nanocarriers encapsulating anti-Alzheimer drug for nasal delivery to central nervous system

Corace, Giuseppe (2012) Multifunctional nanocarriers encapsulating anti-Alzheimer drug for nasal delivery to central nervous system, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze farmaceutiche, 24 Ciclo. DOI 10.6092/unibo/amsdottorato/4545.
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Abstract

Alzheimer's disease (AD) is a fatal neurodegenerative condition characterized clinically by progressive memory loss and irreversible cognitive deterioration. It has been shown that there is a progressive degeneration of the brain cholinergic neurons which leads to the appearance of cognitive symptoms of the disease. The aim of this work was the formulation of multifunctional nanocarriers for nasal administration of tacrine-HCl (THA). This route has many advantages; in particular is possible to convey the drug directly to the Central Nervous System, through the olfactory bulb. In particular, were prepared Albumin nanoparticles carrying beta cyclodextrin and two different beta cyclodextrin derivatives (hydroxypropyl beta cyclodextrin and sulphobutylether beta cyclodextrin), and Multifunctional liposomes, prepared using traditional excipients (cholesterol and phosphatidylcholine), partly enriched with α-tocopherol (Toc) and/or polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) (Ω3). Both nanosystems were characterized in terms of size, Zeta potential and encapsulation efficiency. Were also evaluated their functional properties such as mucoadhesion and permeability, using an ex-vivo assay based on nasal sheep mucosa. On Liposomes were also assessed drug neuronal uptake, cell toxicity, antioxidant and, cytoprotective activity in the human neuronal cell line SH-SY5Y and finally tocopherol trans-membrane diffusion. Both the nanocarriers produced presented excellent properties and a high potential as new systems for CNS-delivery of anti-Alzheimer drugs via the nasal route.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Corace, Giuseppe
Supervisore
Dottorato di ricerca
Scuola di dottorato
Scienze chimiche
Ciclo
24
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
multifunctional liposomes; Alzheimer's disease; nasal administration; enhanced permeation; neuronal uptake;
URN:NBN
DOI
10.6092/unibo/amsdottorato/4545
Data di discussione
20 Aprile 2012
URI

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