The regulation of Satellite Cells during skeletal muscle regeneration and neuromuscular disease.

Scaramozza, Annarita (2012) The regulation of Satellite Cells during skeletal muscle regeneration and neuromuscular disease., [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze biomediche: progetto n. 5 "Scienze morfologiche umane e molecolari", 24 Ciclo. DOI 10.6092/unibo/amsdottorato/4258.
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Abstract

Skeletal muscle possesses the remarkable capacity to complete a rapid and extensive regeneration, even following severe damage. The regenerative ability of skeletal muscle relies on Satellite Cells (SCs), a population of muscle specific adult stem cells. However, during aging or under several pathological conditions, the ability of skeletal muscle to fully regenerated is compromised. Here, a morphological and molecular study on SCs from patients affected by ALS is described. Moreover, the role of the cell cycle regulator P16Ink4a during skeletal muscle regeneration and aging has been investigated.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Scaramozza, Annarita
Supervisore
Dottorato di ricerca
Scuola di dottorato
Scienze mediche e chirurgiche cliniche
Ciclo
24
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
Skeletal Muscle Regeneration, Satellite Cells, Amyotrophic Lateral Sclerosis, P16Ink4a
URN:NBN
DOI
10.6092/unibo/amsdottorato/4258
Data di discussione
16 Gennaio 2012
URI

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