Novel membranes for hemodialysis application

De Pascale, Matilde (2021) Novel membranes for hemodialysis application, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Ingegneria civile, chimica, ambientale e dei materiali, 33 Ciclo. DOI 10.48676/unibo/amsdottorato/9605.
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The present work is focused on the synthesis and characterization of novel materials for hemodialysis applications. Cellulose acetate was chosen as base polymer for the preparation of porous Mixed Matrix Membrane adsorbers (MMMAs) and for the synthesis of hybrid ultrafiltration membranes. Hemodialysis is a renal replacement therapy used to eliminate,the waste products and excess fluids accumulating in the blood of people affected by an end stage renal disease. The main environmental drawback associated to it is the large water consumption. The MMMAs were prepared with the porpoise of eliminating waste metabolites (uremic toxins) from the spent dialysate solution, with the prospective limiting the consumption of water related to the process. Batch tests of MMMAs showed that the removal of uric acid is almost complete while the one of urea and creatinine is limited to a 20/30 %. The thinking behind the concept of MMMAs was aimed to develop a small a lab scale chromatographic cartridge to continuously remove uremic toxins from an aqueous feed solution. The cartridge was packed with MMMAs and tested with a mixture of toxins. Experiments results shown a promising removal capability of the system even if the necessity of a higher surface area to achieve better efficiency is denoted. The other important issue related to hemodialysis is the assessment of an overall mass transfer rates in hemodialyzers. The mass transfer correlations proposed in literature do not take into account the effect of permeation and are developed for turbulent flow regime. Therefore, hybrid cellulose acetate/Silica ultrafiltration membranes were prepared to characterize a surrogate system of an artificial kidney (AK) in terms of fluid mechanics and mass transfer. The effect of surface roughness and suction on the velocity profiles was determined and a new dimensionless mass transfer correlation accounting for permeation was developed.

Tipologia del documento
Tesi di dottorato
De Pascale, Matilde
Dottorato di ricerca
Settore disciplinare
Settore concorsuale
Parole chiave
Hemodialysis procedure Water consumption Uremic toxins Zeolites Activated carbons Cellulose Acetate porous Mixed Matrix Membranes adsorbers Cellulose acetate/Silica hybrid ultrafiltration membranes Surrogate system of an artificial kidney (AK) Mass transport coefficients and correlations
Data di discussione
16 Marzo 2021

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