Defective Oxidative Phosphorylation Induced by CoQ10 Depletion Reshaped Cancer Metabolism: Implications for Cancer Targeting

Cancer cells usually featured with variable oxidative phosphorylation (OXPHOS) during its progression, leading to metabolic reprogramming. We aimed to study different metabolic propensity of cancer cells with different oxidative phosphorylation (OXPHOS) activity. In particular, we focused on study how glycolysis was remodeled to meet bioenergetic, biosynthetic and redox requirements. Also, we aimed to investigate the dependence of cancer cells on a specific metabolic pathway or metabolic enzymes. This study can provide an insightful understanding of metabolic reprogramming in cancer cells with different oxidative phosphorylation (OXPHOS) activity. And it can offer potential selective targets for cancer therapy.