Biological effects of bioactive components and extracts derived from edible plants commonly used in human nutrition

Danesi, Francesca (2009) Biological effects of bioactive components and extracts derived from edible plants commonly used in human nutrition, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze degli alimenti, 21 Ciclo. DOI 10.6092/unibo/amsdottorato/1596.
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The main aim of this PhD research project was the evaluation of the biological effects of bioactive compounds derived from edible plants, with particular attention on their possibility to counteract oxidative damage and inflammation. After a preliminary study of in vitro antioxidant activity, regarding the modification eventually occurring after home freezing and cooking of edible vegetables, cultured mammalian cells were used as experimental model systems. Soluble extract and essential oils derived from different cultivars of Brassicaceae and Lamiaceae were tested as possible tools for the counteraction of the oxidative damage due to reactive oxygen species (ROS), underlining differences related to cultivar and agronomic techniques. Since accumulating evidence indicates that phytochemicals exhibit several additional properties in complex biological systems, a nutrigenomic approach was used to further explain the biological activity of a green tea extract, and to evidence the anti-inflammatory role of bioactive compounds derived from different foods. Overall, results obtained could contribute to a better understanding of the potential health benefit of plant foods.

Tipologia del documento
Tesi di dottorato
Danesi, Francesca
Dottorato di ricerca
Scuola di dottorato
Scienze agrarie
Settore disciplinare
Settore concorsuale
Parole chiave
Antioxidants, bioactive compounds, gene expression, inflammation, oxidative stress, phytochemicals, transcription factors, vegetables.
Data di discussione
27 Maggio 2009

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