Monte Carlo Simulations of Novel Scintillator Detectors and Dosimetry Calculations

Lo Meo, Sergio (2009) Monte Carlo Simulations of Novel Scintillator Detectors and Dosimetry Calculations , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Fisica, 21 Ciclo. DOI 10.6092/unibo/amsdottorato/1583.
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Monte Carlo (MC) simulation techniques are becoming very common in the Medical Physicists community. MC can be used for modeling Single Photon Emission Computed Tomography (SPECT) and for dosimetry calculations. 188Re, is a promising candidate for radiotherapeutic production and understanding the mechanisms of the radioresponse of tumor cells "in vitro" is of crucial importance as a first step before "in vivo" studies. The dosimetry of 188Re, used to target different lines of cancer cells, has been evaluated by the MC code GEANT4. The simulations estimate the average energy deposition/per event in the biological samples. The development of prototypes for medical imaging, based on LaBr3:Ce scintillation crystals coupled with a position sensitive photomultiplier, have been studied using GEANT4 simulations. Having tested, in the simulation, surface treatments different from the one applied to the crystal used in our experimental measurements, we found out that the Energy Resolution (ER) and the Spatial Resolution (SR) could be improved, in principle, by machining in a different way the lateral surfaces of the crystal. We have then studied a system able to acquire both echographic and scintigraphic images to let the medical operator obtain the complete anatomic and functional information for tumor diagnosis. The scintigraphic part of the detector is simulated by GEANT4 and first attempts to reconstruct tomographic images have been made using as method of reconstruction a back-projection standard algorithm. The proposed camera is based on slant collimators and LaBr3:Ce crystals. Within the Field of View (FOV) of the camera, it possible to distinguish point sources located in air at a distance of about 2 cm from each other. In particular conditions of uptake, tumor depth and dimension, the preliminary results show that the Signal to Noise Ratio (SNR) values obtained are higher than the standard detection limit.

Tipologia del documento
Tesi di dottorato
Lo Meo, Sergio
Dottorato di ricerca
Scuola di dottorato
Scienze matematiche, fisiche ed astronomiche
Settore disciplinare
Settore concorsuale
Data di discussione
21 Maggio 2009

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