Role of bioactive compounds in the gastrointestinal host-pathogen interaction of poultry and swine

Giovagnoni, Giulia (2023) Role of bioactive compounds in the gastrointestinal host-pathogen interaction of poultry and swine, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze veterinarie, 35 Ciclo.
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The better understanding of mechanisms at the basis of host-pathogen interaction can represent a valid tool to increase productivity and contain economic losses in animal production through the maintenance of intestinal homeostasis. With this project, three preliminary in vitro studies were conducted with the aim of investigating how bioactive compounds could influence mechanisms of host-pathogen interaction in poultry and swine. Different panels of nature identical compounds, medium chain fatty acids, and plant extracts were employed against strains of Salmonella Typhimurium, Brachyspira hyodysenteriae, and Salmonella Enteritidis, respectively. When bacterial field strains were tested, the comparison between natural compounds and antibiotics was examined, with the aim of evaluating the role of the substances in the antibiotic-resistance context. Results demonstrate that bioactive compounds have positive effects on the host, the pathogen, or both in different experimental conditions. Additionally, when compared to antibiotics, bioactive compounds have proven to be valid alternatives to address the phenomenon of antibiotic resistance.

Tipologia del documento
Tesi di dottorato
Giovagnoni, Giulia
Dottorato di ricerca
Settore disciplinare
Settore concorsuale
Parole chiave
Host-pathogen interaction; botanicals; plant extracts; nature identical compounds; organic acids; Salmonella; Brachyspira; poultry; swine; gastrointestinal tract; intestinal homeostasis; antibiotic resistance
Data di discussione
19 Giugno 2023

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