Synthesis and characterization of implants for bone substitutions made of biomedical apatites containing silicon

Sprio, Simone (2008) Synthesis and characterization of implants for bone substitutions made of biomedical apatites containing silicon, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze chimiche, 20 Ciclo. DOI 10.6092/unibo/amsdottorato/1049.
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Abstract

In the last decades the development of bone substitutes characterized by a superior biomimetism has become of particular interest, owing to the increasing economic and societal impact of the bone diseases. In the present work of research the development of bone substitutes characterized by improved biomimetism, has been faced in a chemical, structural and morphological perspective. From a chemical point of view, it has been developed the synthesis of hydroxyapatite powders, exhibiting multiple ionic substitutions in both cationic and anionic sites, so to simulate the chemical composition of the natural bone. Particular emphasis has been given to the effect of silicon on the chemical-physical and solubility properties of the obtained hydroxyapatites. From a structural point of view, it has been developed the synthesis of ceramic composite materials, based on hydroxyapatite and calcium silicates, employed both as a reinforcing phase, to raise the mechanical strength of the composite compared to hydroxyapatite, and as a bioactive phase, able to increase the bioactivity properties of the whole ceramic. Finally the unique morphological features of the bone were mimicked by taking inspiration by Nature, so that native wood structures were treated in chemical and thermal way to obtain hydroxyapatite porous materials characterized by the same morphology as the native wood. The results obtained in the present work were positive in all the three different areas of investigation, so to cover the three different aspects of biomimetism, chemical, structural and morphological. Anyway, only at the convergence of the three different fields it is possible to find out the best solutions to develop the ideal bone-like scaffold. Thus, the future activity should be devoted to solve the problems at the borderline between the different research lines, which hamper this convergence and in consequence, the achievement of a bone scaffold able to mimic the various aspects exhibited by the bone tissue

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Sprio, Simone
Supervisore
Co-supervisore
Dottorato di ricerca
Ciclo
20
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
bioceramics hydroxyapatite bone scaffolds biomimetism mechanical properties hierarchical structures
URN:NBN
DOI
10.6092/unibo/amsdottorato/1049
Data di discussione
16 Aprile 2008
URI

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