Short course accelerated radiation therapy in palliative care

Capuccini, Jenny (2018) Short course accelerated radiation therapy in palliative care, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Oncologia, ematologia e patologia, 30 Ciclo. DOI 10.6092/unibo/amsdottorato/8411.
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Abstract

Palliative radiotherapy is a key resource for symptoms control and improvement patient's life expectancy in advanced stage of illness. The most common symptoms that afflict this type of patients are pain, bleeding, dysphagia, obstruction, vomiting, nausea. Most of these can benefit from a hypo-fractionated radiation treatment with a good percentage of complete responses, variable depending on the symptom considered, but on average 56-70%. Normally a hypo-fractionated treatment, excluding uncomplicated bone metastases where the single fraction (800 cGy in 1 fraction) is the standard, provides for 30 Gy delivered in 10 fractions (1 fraction / day) or 20 Gy in 5 fractions (1 fraction / day). SHARON Project (Short Course Accelerated Radiation Therapy), based on dose-escalation Phase I-II studies that defined the MDT (maximum tolerated dose), is made up of 7 randomized Phase III trials (1:1 on Simon's design) that aim to compare the effectiveness on the symptom control of a conventional hypo-fractionationated radiotherapy compared with an accelerated hypofractionationated treatment. 4 Specifically, the fractionation we propose provides the delivery of 4.5-5 Gy twice a day at a distance of 6-8 hours for two consecutive days. GTV will be identified by macroscopic lesion (detailed in the single protocol), CTV by GTV + a margin of 2 cm and the PTV from CTV + 1 cm of isotropic margin. There will be described the results of the Sharon-Bone Phase I-II trial, Sharon Head and Neck Phase I-II trial and Sharone Elderly (pooled analysis phase I-II trials) and the seven randomized Phase III trials for all the described body regions (Abdomen RT 15-01, Brain RT 15-02, Thorax RT 15-03, Pelvis RT 15-04, H&N RT 15-05, Bone RT 15-06, Esophagus RT 15-07)

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Capuccini, Jenny
Supervisore
Dottorato di ricerca
Ciclo
30
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
palliative radiotherapy,short course radiotherapy,quality of life,dose-escalation,maximum tolerated dose
URN:NBN
DOI
10.6092/unibo/amsdottorato/8411
Data di discussione
9 Maggio 2018
URI

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