Innovative therapeutic approaches for the atrophic Age-related Macular Degeneration (“dry” AMD)

Caligiana, Alberto (2020) Innovative therapeutic approaches for the atrophic Age-related Macular Degeneration (“dry” AMD), [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze biotecnologiche e farmaceutiche, 32 Ciclo.
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Abstract

Finally, during the period abroad of my PhD program, I studied through an RNA-sequencing strategy how statins might exert a protective role in AMD. Following previous findings from my host laboratory, I investigated if treating ARPE-19 cells and primary culture of RPE cells with different concentrations of Atorvastatin could induce modification in expression of genes related to fundamental pathways as phagocytosis, debris removal and lipid metabolism. I was able to detect any genes involved in these modifications, without being able to prove a clear trend indicating a massive pathways involvement.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Caligiana, Alberto
Supervisore
Dottorato di ricerca
Ciclo
32
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
AMD, eye, therapy, integrin, antagonism
URN:NBN
Data di discussione
3 Aprile 2020
URI

Altri metadati

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