Novel insights into gold(I) chemistry: from anticancer activity to new synthetic methodologies.

De Nisi, Assunta (2018) Novel insights into gold(I) chemistry: from anticancer activity to new synthetic methodologies., [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Chimica, 30 Ciclo. DOI 10.6092/unibo/amsdottorato/8597.
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Abstract

The work herein presented, embraces various aspects of gold chemistry: the documentation of novel [alkynyl(triphenylphosphine)gold(I)] complexes carrying differently substituted propargylic amines and their pharmacological investigation on a series of cancer cell lines and the investigation of the dearomative cycloaddition reaction of indoles with electron-rich allenes catalysed by commercially available gold(I) complexes that show competence in performing the chemo-, regio- and diastereoselective formal [2+2]-cycloaddition between a wide range of substrates under mild conditions. It has also been developed the combined efficiency of Bu4N+ and F− ions in performing a cascade sequence involving intramolecular hydroamination of the C–C triple bond, cleavage of silyl-protecting groups and site-selective sigmatropic aza-Cope-type [3,3]-rearrangement.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
De Nisi, Assunta
Supervisore
Co-supervisore
Dottorato di ricerca
Ciclo
30
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
gold catalysis, anticancer drugs
URN:NBN
DOI
10.6092/unibo/amsdottorato/8597
Data di discussione
9 Maggio 2018
URI

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