Design and Characterization of Luminescent Silica Nanoparticles

Petrizza, Luca (2015) Design and Characterization of Luminescent Silica Nanoparticles, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Chimica, 27 Ciclo. DOI 10.6092/unibo/amsdottorato/7091.
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Abstract

The aim of this thesis was to design, synthesize and characterize dye-doped silica nanoparticles (DDSNPs) to be used as chemosensors or labels in bioanalytical applications. DDSNPs represent one of the most versatile and useful components in nanomedicine displaying important features such as high colloid stability in water, low toxicity, one-pot inexpensive synthesis and tunable fluorescence emission. Starting from the one-pot and highly reproducible synthesis of “silica-core/PEG shell” DDSNPs based on the use of micelles of Pluronic F127, in which take place both hydrolysis and condensation of the silica precursor and of the dyes functionalized with a triethoxysilane group, we developed DDSNPs suitable for optical and optoacustic imaging, drug loading and chemical sensing obtaining very interesting results for the further development of nanomedicine.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Petrizza, Luca
Supervisore
Dottorato di ricerca
Scuola di dottorato
Scienze chimiche
Ciclo
27
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
nanoparticles fluorescence dye optical imaging chemosensor drug delivery cell labeling flow cytometry luminescence quantum yield silica
URN:NBN
DOI
10.6092/unibo/amsdottorato/7091
Data di discussione
12 Maggio 2015
URI

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