Innovative asymmetric organocatalytic processess: en route to the synthesis of biologically relevant compounds

Caruana, Lorenzo (2015) Innovative asymmetric organocatalytic processess: en route to the synthesis of biologically relevant compounds, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Chimica, 27 Ciclo. DOI 10.6092/unibo/amsdottorato/6995.
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Abstract

This doctoral thesis deals with the development of novel organocatalytic strategies for asymmetric transformation. The intrinsic versatility of organocatalysis and the use of different activation modes have been exploited to achieve new catalytic enantioselective processes, towards the synthesis of biologically relevant scaffolds. The most investigated organocatalytic system have been those based on H-bond interaction (such as chiral thioureas or phosphoric acids) as well as the ones based on aminocatalysis. Despite conceptually distinct, the transformations detailed in this Thesis are linked together by simple and recurring modes of activation, induction and reactivity, promoted by the catalysts employed. The chemical diversity of the challenges encountered allows to get a precious overall view on organocatalysis, highlighting that enormous chemical diversity can be created by judicious choice of select catalyst.

Abstract
Tipologia del documento
Tesi di dottorato
Autore
Caruana, Lorenzo
Supervisore
Co-supervisore
Dottorato di ricerca
Scuola di dottorato
Scienze chimiche
Ciclo
27
Coordinatore
Settore disciplinare
Settore concorsuale
Parole chiave
Organocatalysis Asymmetric Synthesis Povarov Indoles Aldehydes Ortho/para quinone methides H-bonding catalysis chiral phosphoric acid aminocatalysis
URN:NBN
DOI
10.6092/unibo/amsdottorato/6995
Data di discussione
7 Aprile 2015
URI

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