Methods for the estimation of the cortical activity and connectivity during cognitive tasks in humans

Toppi, Jlenia (2013) Methods for the estimation of the cortical activity and connectivity during cognitive tasks in humans , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Bioingegneria, 25 Ciclo. DOI 10.6092/unibo/amsdottorato/5271.
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The research activity characterizing the present thesis was mainly centered on the design, development and validation of methodologies for the estimation of stationary and time-varying connectivity between different regions of the human brain during specific complex cognitive tasks. Such activity involved two main aspects: i) the development of a stable, consistent and reproducible procedure for functional connectivity estimation with a high impact on neuroscience field and ii) its application to real data from healthy volunteers eliciting specific cognitive processes (attention and memory). In particular the methodological issues addressed in the present thesis consisted in finding out an approach to be applied in neuroscience field able to: i) include all the cerebral sources in connectivity estimation process; ii) to accurately describe the temporal evolution of connectivity networks; iii) to assess the significance of connectivity patterns; iv) to consistently describe relevant properties of brain networks. The advancement provided in this thesis allowed finding out quantifiable descriptors of cognitive processes during a high resolution EEG experiment involving subjects performing complex cognitive tasks.

Tipologia del documento
Tesi di dottorato
Toppi, Jlenia
Dottorato di ricerca
Scuola di dottorato
Scienze e ingegneria dell'informazione
Settore disciplinare
Settore concorsuale
Parole chiave
Effective Connectivity, Partial Directed Coherence, Time-Varying Connectivity, Statistical Validation, Multiple Comparisons, Graph Theory
Data di discussione
12 Aprile 2013

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