Statistical methods for biomedical signal analysis and processing

Palladini, Alessandro (2009) Statistical methods for biomedical signal analysis and processing, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Tecnologie dell'informazione, 21 Ciclo. DOI 10.6092/unibo/amsdottorato/1358.
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Statistical modelling and statistical learning theory are two powerful analytical frameworks for analyzing signals and developing efficient processing and classification algorithms. In this thesis, these frameworks are applied for modelling and processing biomedical signals in two different contexts: ultrasound medical imaging systems and primate neural activity analysis and modelling. In the context of ultrasound medical imaging, two main applications are explored: deconvolution of signals measured from a ultrasonic transducer and automatic image segmentation and classification of prostate ultrasound scans. In the former application a stochastic model of the radio frequency signal measured from a ultrasonic transducer is derived. This model is then employed for developing in a statistical framework a regularized deconvolution procedure, for enhancing signal resolution. In the latter application, different statistical models are used to characterize images of prostate tissues, extracting different features. These features are then uses to segment the images in region of interests by means of an automatic procedure based on a statistical model of the extracted features. Finally, machine learning techniques are used for automatic classification of the different region of interests. In the context of neural activity signals, an example of bio-inspired dynamical network was developed to help in studies of motor-related processes in the brain of primate monkeys. The presented model aims to mimic the abstract functionality of a cell population in 7a parietal region of primate monkeys, during the execution of learned behavioural tasks.

Tipologia del documento
Tesi di dottorato
Palladini, Alessandro
Dottorato di ricerca
Scuola di dottorato
Scienze e ingegneria dell'informazione
Settore disciplinare
Settore concorsuale
Parole chiave
biomedical signals, statistical signal processing methods, ultrasound imaging systems, prostate cancer, ultrasound images deconvolution, computer aided cancer diagnosis, neural activity recording, neural signal modeling, neural networks, liquid state machines. machine learning
Data di discussione
26 Marzo 2009

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