A take on complexity: bio-molecules and human metabolism interaction modelling for health and nutrition with machine learning

Mengucci, Carlo (2022) A take on complexity: bio-molecules and human metabolism interaction modelling for health and nutrition with machine learning, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Nanoscienze per la medicina e per l'ambiente, 34 Ciclo. DOI 10.48676/unibo/amsdottorato/10198.
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The advent of omic data production has opened many new perspectives in the quest for modelling complexity in biophysical systems. With the capability of characterizing a complex organism through the patterns of its molecular states, observed at different levels through various omics, a new paradigm of investigation is arising. In this thesis, we investigate the links between perturbations of the human organism, described as the ensemble of crosstalk of its molecular states, and health. Machine learning plays a key role within this picture, both in omic data analysis and model building. We propose and discuss different frameworks developed by the author using machine learning for data reduction, integration, projection on latent features, pattern analysis, classification and clustering of omic data, with a focus on 1H NMR metabolomic spectral data. The aim is to link different levels of omic observations of molecular states, from nanoscale to macroscale, to study perturbations such as diseases and diet interpreted as changes in molecular patterns. The first part of this work focuses on the fingerprinting of diseases, linking cellular and systemic metabolomics with genomic to asses and predict the downstream of perturbations all the way down to the enzymatic network. The second part is a set of frameworks and models, developed with 1H NMR metabolomic at its core, to study the exposure of the human organism to diet and food intake in its full complexity, from epidemiological data analysis to molecular characterization of food structure.

Tipologia del documento
Tesi di dottorato
Mengucci, Carlo
Dottorato di ricerca
Settore disciplinare
Settore concorsuale
Parole chiave
1H NMR, Machine Learning, Metabolomics, Health, Nutrition, Omic Sciences
Data di discussione
22 Giugno 2022

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