New catalytic strategies for the synthesis of complex (hetero)-cyclic compounds

Cerveri, Alessandro (2022) New catalytic strategies for the synthesis of complex (hetero)-cyclic compounds, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Chimica, 34 Ciclo. DOI 10.48676/unibo/amsdottorato/10102.
Documenti full-text disponibili:
[img] Documento PDF (English) - Richiede un lettore di PDF come Xpdf o Adobe Acrobat Reader
Disponibile con Licenza: Salvo eventuali più ampie autorizzazioni dell'autore, la tesi può essere liberamente consultata e può essere effettuato il salvataggio e la stampa di una copia per fini strettamente personali di studio, di ricerca e di insegnamento, con espresso divieto di qualunque utilizzo direttamente o indirettamente commerciale. Ogni altro diritto sul materiale è riservato.
Download (6MB)


The aim of this Doctoral Thesis is the development of new catalytic transformation for efficient and sustainable processes, with the main purpose of easily access the incredible diversity and complexity of bio-relevant compounds. The tuning of general synthetic strategies is a flourishing field in organic chemistry, and can rapidly give access to libraries of products with small to big modifications from a hypothetical lead compound. Whit this in mind, in the modern era of organic synthesis, many aspects are pivotal in the design of a new catalytic procedure, such as reproducibility, generality over the main functional groups, mild conditions and easily accessible starting materials and catalysts. Particularly, another fundamental aspect is the generation of complexity in one single step, to conveniently assemble the scaffold of the class of compounds studied. During the course of my PhD, two main strategies were analyzed to tackle these challenges, namely de-aromatization and ring construction through cyclization. These methodologies have been deeply investigated both in organo- and metal-catalyzed fashions, and conceptually new protocols have been developed. Particular attention has been devoted at the study and optimization of the reaction conditions and catalyst structure, in order to maximize yield and selectivity of the processes as well as minimizing the catalyst loading and using the mildest conditions. The substrate scope has been thoroughly investigated to demonstrate the broad applicability of the proposed transformations, as well as the performance of synthetic elaborations illustrating the usefulness of the developed methods. Despite the conceptual diversity, the proposed protocols are connected by their potential further development into useful tools for the bio-molecule synthetic scenario.

Tipologia del documento
Tesi di dottorato
Cerveri, Alessandro
Dottorato di ricerca
Settore disciplinare
Settore concorsuale
Parole chiave
Catalysis, Sustainability, de-Aromatization, Ring Construction
Data di discussione
22 Marzo 2022

Altri metadati

Statistica sui download

Gestione del documento: Visualizza la tesi